How fast does clomid raise testosterone

The timeline is a guess and often dependent on how long testosterone replacement therapy has been in play. Clomid does not work this way. Clomid has been around for quite some time. And most men, when initially prescribed will google the medication and find it used for women and fertility. So why is your doctor prescribing it for low testosterone? Clomid is a different approach to increase testosterone and fertility in men. To explore this in-depth, get your science book back out because we are about to go to school.

The endocrine system comes into play, which can seem slightly complex. In men with normal levels of testosterone, the pituitary gland in the brain releases luteinizing hormone LH into the bloodstream. Results: The mean age was 39 years, and the mean pretreatment testosterone and estrogen levels were By the first follow-up visit weeks , the mean testosterone level rose to There were no side effects reported by the patients. Most of these men were married in a stable heterosexual relationship; the single men were in a steady relationship for at least 6 months.

A home log was kept in which the couple recorded the number of sexual attempts and successes at intercourse. The men who failed did not notice any change in their sexual activity. No men reported side effects caused by clomiphene citrate. Of the men who began taking clomiphene, This population was the basis of the present study. Serum luteinizing hormone and free testosterone levels were drawn between and Of these men with low baseline testosterone levels, or The normal range for free testosterone is age related and is reported as 9.

Patients were categorized as having complete, partial, or no response based on self-reported erectile function following clomiphene therapy. When ordinal categorical variables were compared, the linear-by-linear test of association was used. Paired t -tests were used to compare the mean hormone levels within each response group before and after treatment with clomiphene citrate. Paired t -tests were repeated to assess differences in age within response groups with selected comorbid conditions.

Independent t -tests assuming equal variance were used to detect significant differences between response groups in the change or delta in luteinizing hormone and free testosterone levels following treatment. Finally, multivariate analyses were conducted to determine the independent effects of patient characteristics and clinical risk factors on the likelihood of responding to clomiphene. The three response categories were collapsed into a binary variable, where 1 denoted any response to treatment ie, positive or partial and 0 denoted no response.

Variables deemed clinically relevant or statistically significant in univariate analyses were selected for entry into multivariate models. Diagnostic analyses eg, tests of multicollinearity and analysis of residuals were conducted to ensure that variables were appropriately entered in the model and critical statistical assumptions were not violated.

When odds ratios for scaled predictors were large, regression models were run with and without the parameter of interest and goodness-of-fit statistics were then compared. All P values are two-tailed. The mean age of the men was A total of 84 men Figure 1 shows the response rate of the group as a whole.

In all, 67 men Therefore, Figure 2 and Figure 3 show that despite a disparity in clinical response, clomiphene stimulation significantly raised the blood levels of both luteinizing hormone and free testosterone in all groups.

The serum luteinizing hormone level rose in the responders from 3. The serum-free testosterone levels rose from 9. Figure 4 shows the response to clomiphene as a function of age. There was a higher percentage of responders The partial responders were equally divided by age, Table 1 shows the influence of comorbid medical risk factors on the effect of clomiphene-stimulated testosterone levels on erectile function.

A higher number of partial responders and nonresponders were seen in patients with hypertension, diabetes mellitus, coronary artery disease CAD , and those using multiple medications; however, not all of these differences achieved statistical significance. In these comorbidities, the number of men who responded partially to testosterone replacement was between In all, Men with psychosocial comorbidities to their hypogonadism seemed to respond better to correction of the low testosterone, between This appeared to be true for various types of stress, whether because of endogenous chronic anxiety, performance anxiety, or work-related stress.

It is interesting that significant performance anxiety was a greater problem for men who had a partial clomiphene response than for those with no response Table 2 correlates the medical risk factors diabetes, hypertension, CAD, and the use of multiple medications with age. Only the incidence of CAD however differed significantly by age Among partial responders, there was a higher percentage of younger men who had diabetes, CAD, and took multiple medications.

Again, only the incidence of CAD differed significantly by age In non-responders, there was a definite increase in the number of older men in all four of the major medical risk factors. Older nonresponders were significantly more likely to have hypertension than younger nonresponders In the anxiety categories, mild performance anxiety failure was significantly higher in younger responders Logistic regression analysis assessed the effects of relevant clinical variables while controlling for covariates.

Since many variables were inter-related, a correlation matrix was created to assess problems of multicollinearity that would bias regression coefficients and inflate standard error estimates. Plots of residuals and goodness-of-fit statistics for models with and without selected variables were then analyzed. Variables with extremely low frequencies or high correlations with one another were ultimately excluded, because these decrease the predictive validity of the model.

Table 3 shows the final logistic regression model and related parameter estimates. The absence of a venous leak, clinically manifested as early detumescence of sexually stimulated erections, was the second strongest predictor of therapeutic response. Diabetes was the only clinical predictor of patient response that approached statistical significance.

The narrow confidence interval around this estimate indicates that with a slightly higher sample size, the parameter would become significant at or below the 0. Contrary to published literature, cigarette smokers had virtually no difference in response compared with nonsmokers OR, 1. However, this estimate may be attributable to the low number of smokers in the sample.

Finally, patients with CAD were 1. The final three predictors illustrate the relations between previous clinical therapy for ED and clomiphene response. As a result of the wide variety of therapeutic options available to and used by these patients, three different categories were created: yohimbine therapy, Medicated Urethral System for Erection MUSE therapy, and other modalities which included penile injections, vacuum pumps, or rings.

In contrast, the use of other therapeutic devices was a strong and significant predictor of response. Patients who had used alternative therapies were 3. A secondary regression analysis was conducted using backward deletion of parameters to create a bes t -fitting model.

Results confirmed the significance of the variables described previously. A multinomial logistic regression model was also run, using partial response, positive response, and no response categories as levels of the dependent variable. Parameters affecting therapeutic response in previous analyses did not differ significantly when the response was measured as three categories instead of two. Finally, tests for firs t -order interactions between age and clinical characteristics did not provide additional insights, and are therefore not included.

Our data showed that clomiphene citrate can successfully stimulate the hypothalamus to cause increased testicular testosterone production. It was also seen in the presence of common chronic conditions such as diabetes mellitus, hypertension, CAD, and the use of multiple medications. The fact that these conditions were also more prevalent in the older age group seems to indicate that the lack of clinical response may be the result of comorbid medical factors than of age alone.

It has long been established that testosterone is required for libido in men, but there has been debate regarding the extent of its effect on erectile capacity and sexual satisfaction.

The positive effects of testosterone on nocturnal erections have also been shown by others, who reported a positive effect in coital attempts, and in orgasms as well.

At the biochemical level, androgens are necessary for the physiologic erectile response in the corpus cavernosum of the penis. As previously mentioned, acute critical illness decreases testosterone levels, especially by suppressing the central hypothalamic-pituitary axis.

The effect may be mediated through cytokines produced in systemic diseases, including tumor necrosis factor. Iron deposition in the pituitary may cause hypogonadotropic hypogonadism in beta-thalassemia, 48 the effect of which was found to be separate from the production of diabetes in these patients.

Some central suppression of testosterone production was even found during fasting in younger men. A large percentage of our patients had anxiety-related disorders; some had chronic anxiety, while others had performance anxiety, but the most prominent was work-related stress. Excess cortisol suppresses the central hypothalamic—pituitary axis, whether exogenous 52 or endogenous.

Clomiphene stimulation did not elevate the testosterone level out of the normal range, but it remained in the middle of the normal range. Stimulation for 4 months produced levels similar to those in our previous study when the levels were measured after 2 months. Wang et al 58 found that a positive response to testosterone did not improve further when testosterone levels increased from the low-normal to the high-normal range. It is generic and cheap. No shots. Fertility is preserved. No testicular shrinkage.

It has few, if any, side effects and this is usually dose-related. Each patient is different and the response will vary depending on current testosterone level. It is inexpensive and usually covered by health insurance. In lower levels of testosterone, it takes longer to see the benefits of Clomid than with injection therapy. It may also not work, especially in patients over 60 and those with compound medical issues.

Some patients may not see an increase in libido as Clomid does have some mild estrogenic properties. Of course, we follow the labs, just like in TRT, and would correct for an elevated estradiol level if needed anastrozole.

There have been rare reports of vision changes. If this happens, the patient should note very specifically what occurred, how long it lasted, etc. A typical candidate for Clomid is younger and planning on having children soon or in the future. Patients who just do not want to deal with injection or pellet therapy and are willing to accept a lower T level.

Patients who have been on TRT and have decided to have children but want to maintain some increase in testosterone levels. Men who have known low sperm counts. Patients who have a varicocele a problem with the blood vessel around the testes that can cause infertility. The fact that these conditions were also more prevalent in the older age group seems to indicate that the lack of clinical response may be the result of comorbid medical factors than of age alone.

The dosage range is I prefer to start at 25mg every other day for a short trial period and then increase to daily dosing. You will read any number of protocols that involve more complicated patterns of dosing. I prefer to keep it simple. Some authors recommend taking Vitamin E to improve the success of Clomid.

More than iu is not recommended, a much smaller dose is fine. How soon will fertility be improved with Clomid?