When was ad first identified

Palmer used a systematic method in which his agency organized clients into appropriate publications depending on the target audience and market. Despite the emergence of professional advertising agencies, American advertisers in the midth and early 19th century did not demonstrate visible changes in advertising styles. Newspaper advertisements remained a one-column piece with minimal illustrations.

Only a few companies utilized branded advertising to promote their products until tides turned in the lateth century. Starting in the s, American companies began to manufacture standardized products such as soap, canned products, and cigarettes, and sought to attract buyers through a national advertising campaign. Publishing its first issue in , the magazine experienced a quick rise in its popularity, reaching more than 4 million readers by The magazine still exists to this day and has since added a digital version.

In the 20th century, native advertising started to take on different formats. The rise of radio and TV industry in the s and s were a major contributor to the growth of native advertising. On radio, businesses often funded radio programs to sustain their advertisement spots. With the mass production of televisions, more businesses began to advertise their goods to target audiences. With the emergence of the Internet, the 21st century now provides an ideal environment for native advertising.

Modern-day native advertising is no longer constrained to radios or TV programs. The rise of search engine companies like Google, Yahoo and AOL have prompted businesses to promote their services through search ads that automatically help them connect with target customers. Some people with memory problems have a condition called mild cognitive impairment MCI. With MCI, people have more memory problems than normal for their age, but their symptoms do not interfere with their everyday lives.

Movement difficulties and problems with the sense of smell have also been linked to MCI. Some may even revert to normal cognition. Problems can include wandering and getting lost, trouble handling money and paying bills , repeating questions, taking longer to complete normal daily tasks, and personality and behavior changes. People are often diagnosed in this stage. In this stage, damage occurs in areas of the brain that control language, reasoning, conscious thought, and sensory processing, such as the ability to correctly detect sounds and smells.

Memory loss and confusion grow worse, and people begin to have problems recognizing family and friends. They may be unable to learn new things, carry out multistep tasks such as getting dressed, or cope with new situations. In addition, people at this stage may have hallucinations, delusions, and paranoia and may behave impulsively. Ultimately, plaques and tangles spread throughout the brain, and brain tissue shrinks significantly.

Near the end of life , the person may be in bed most or all of the time as the body shuts down. The causes probably include a combination of genetic, environmental, and lifestyle factors. Advances in brain imaging techniques allow researchers to see the development and spread of abnormal amyloid and tau proteins in the living brain, as well as changes in brain structure and function.

Research on normal brain aging is exploring this question. These age-related changes include atrophy shrinking of certain parts of the brain, inflammation, blood vessel damage, production of unstable molecules called free radicals, and mitochondrial dysfunction a breakdown of energy production within a cell.

Some cases are caused by an inherited change in one of three genes. For others, research shows that other genetic components are involved. This may be because people with Down syndrome have an extra copy of chromosome 21, which contains the gene that generates harmful amyloid.

There is a great deal of interest, for example, in the relationship between cognitive decline and vascular conditions such as heart disease , stroke , and high blood pressure , as well as conditions such as diabetes and obesity.

A nutritious diet , physical activity , social engagement , and mentally stimulating pursuits have all been associated with helping people stay healthy as they age.

Researchers are testing some of these possibilities in clinical trials. Some of these conditions may be treatable and possibly reversible. An early diagnosis also helps families plan for the future. They can take care of financial and legal matters , address potential safety issues , learn about living arrangements, and develop support networks. Scientists are exploring many avenues to delay or prevent the disease as well as to treat its symptoms. In ongoing clinical trials, scientists are developing and testing several possible interventions.

Under study are drug therapies aimed at a variety of disease interventions, as well as nondrug approaches such as physical activity, diet, cognitive training, and combinations of these. Precision medicine — getting the right treatment to the right person at the right time — will likely play a major role. Several medications are approved by the U. All of these drugs work by regulating neurotransmitters, the chemicals that transmit messages between neurons.

They may help reduce symptoms and help with certain behavioral problems. They are effective for some but not all people and may help only for a limited time. A doctor or specialist will likely perform tests, such as a PET scan or analysis of cerebrospinal fluid, to look for evidence of amyloid plaques and help decide if the treatment is right for the patient. This process requires an additional study after approval to confirm the anticipated clinical benefit.