Why is lasix given during blood transfusion

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Lung Disease. Drug: Furosemide Drug: Saline. Phase 3. Study Type :. It results in difficult breathing and low oxygen levels. The use of diuretics water pills in an intravenous form has been recommended to prevent TACO, but there are no studies to date. Accordingly, many doctors pre-medicate their blood transfusion recipients with loop diuretics.

The goal of our review was to determine whether pre-medicating blood transfusion recipients with loop diuretics prevents complications of blood transfusion. Our review of four studies and participants determined that there is not enough high-quality evidence about the clinically relevant benefits or harms of using loop diuretics to prevent complications of blood transfusion.

There was insufficient evidence to determine whether premedicating people undergoing blood transfusion with loop diuretics prevents clinically important transfusion-related morbidity. Due to the continued use of prophylactic loop diuretics during transfusions, and because this review highlights the absence of evidence to justify this practice, well-conducted RCTs are needed. Given the high mortality, severe morbidity and increasing incidence of transfusion-associated circulatory overload, determining the therapeutic utility of pre-transfusion loop diuresis is an urgent need.

Blood transfusions are associated with significant morbidity and mortality. Please refer to this study by its ClinicalTrials. More Information. Furosemide Anemia LV dysfunction blood transfusion. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: furosemide Drug: placebo normal saline.

Not Applicable. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :.